Autoimmune process and its relationship to ms

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autoimmune process and its relationship to ms

This steady rise in autoimmunity is also seen in MS, a debilitating disease autoimmune diseases,” Professor Aaron Lerner, from the Technion Faculty of Researchers investigated the correlation between autoimmunity and. There is less evidence that MS is a classical autoimmune disease, even Whether they are also primary effectors in the disease process is unknown. The fifth criterion is the correlation between the autoantigen or the. Immune deficiency diseases decrease the body's ability to fight that suppress the immune system can be used to treat multiple sclerosis.

Role of T Cells 5. These T cells express a number of transcription factors including FoxP3 and other molecules [ 4647 ]. These cells play a major role in downregulating the immune response [ 48 — 50 ]. These Th17 cells induce most of the pathology in EAE. These cells have been identified in MS lesions, where they may serve as important effectors.

The mechanism of suppression is by the secretion of factors such as IL These experiments have been relatively successful in EAE; however, the approach has been less effective in human patients. All of the T-cell lines isolated from the peripheral blood were of the CD4 phenotype [ 57 ].

Investigators have examined peripheral blood lymphocytes from MS patients and other neurological controls in effort to study specific T-cell populations against purified human MBP and other brain antigens [ 58 ]. Unfortunately, they discerned only minor differences between MS patients and normal controls as to the specificity of the response to any brain tissue antigens.

The majority of responses were found in patients with chronic progressive MS, a phase when T cells are least active in the disease. These results also have raised concerns about the specificity of the T-cell immune response to myelin antigens in MS patients given the not easily discernible differences between MS patients and normal individuals.

They compared this to animals with EAE and demonstrated expansion of Th17 lymphocytes from the blood of healthy controls as well as from patients with relapsing MS. The same findings were also present in the experimental model. However, the presence of Th17 cells does not automatically prove that they play a role in pathogenesis [ 62 ]. No data is available that deletion of Th17 cells improves MS or that elevated Th17 cells in lesions correlate with disability.

However, in the midst of an inflammatory process such as MS, class I MHC is observed in astrocytes, oligodendrocytes, and neurons and even rarely on axons [ 63 ]. Some of the cytotoxic T cells react against autoantigens such as myelin-basic protein [ 72 ].

Environmental factors in autoimmune diseases and their role in multiple sclerosis

If these cells traveled randomly in the CNS, then presumably their CD3 junction region length would show a normal Gaussian distribution. Strong evidence suggests that perforin contributes to axonal injury in the MS plaque Figure 2. These cells secreted lymphotoxin and other cytokines, which play a critical role in the evolution of the progressive phase of the disease. Perforin mediates axonal transection in multiple sclerosis MS and correlates with neurological disability.

autoimmune process and its relationship to ms

Cytotoxic T cells secrete perforin in the form of granules along with granzymes. This results in holes in the membrane of the target cells, causing leakage of intracellular material, which results in cell death. It was further demonstrated that AQP4-reactive antibodies appear in the pathologic lesions [ 79 ] and that levels of AQP4 antibody and disease activity were correlated [ 80 ].

NMO is associated with other autoimmune disorders [ 20 ]. Given the autoimmune hypothesis associated with NMO, we hypothesized that PLEX, a conventional method to remove circulating autoantibodies in patients, would be beneficial.

Interestingly, PLEX proved to be a highly successful treatment for NMO arguing in favor of an immune-mediated pathogenesis of this disease [ 81 ]. In line with the autoimmune-mediated hypothesis, humoral immunity-suppressing drugs such as mitoxantrone hydrochloride [ 82 ] a synthetic anthracenedione that was approved for the treatment of worsening relapsing-remitting and secondary progressive MSmycophenolate mofetil [ 83 ] an immunosuppressive therapyand rituximab [ 84 ] a B-cell depleting therapy were demonstrated to be beneficial for treatment of NMO.

De Parratt and Prineas recently described an abrupt destruction of perivascular astrocytes in patients with NMO that preceded oligodendrocyte apoptosis in early lesions. Their findings add to the experimental evidence that serum antibody directed against astrocytes present in a high proportion of patients with NMO is pathogenic.

In addition, their data supports a new definition of the disease based on pathology: NMO is a demyelinating disease characterized pathologically by multifocal lesions disseminated in time and space and in which demyelination is secondary to acute destruction of perivascular astrocytes [ 85 ]. However, Takano et al. An Alternate Hypothesis for MS Pathogenesis An attractive hypothesis to explain the immune-mediated pathogenesis of MS is that it is induced by an infectious agent.

Even though no infectious agent has convincingly been demonstrated in MS, there is experimental evidence to support the hypothesis. Experimental Evidence for Virus-Induced Demyelination Experimental infection of laboratory animals with various viruses induces demyelination in the CNS.

autoimmune process and its relationship to ms

The disease model is chronic-progressive in susceptible mice, a striking contrast to the much-used autoimmune EAE model. Two salient features make it the best-suited model for studying MS. There is evidence of an immune response to virally infected cells [ 8889 ] as well as autoimmune response triggered by viral infection in the CNS [ 90 ], both of which are potentially similar to MS. TMEV infection of oligodendrocytes results in cell lysis and liberation of more virions [ 92 ].

On the contrary, infection of TMEV in macrophages is restricted and results in their apoptosis.

Environmental factors in autoimmune diseases and their role in multiple sclerosis

Virus spreads from macrophages to other macrophages and oligodendrocytes, adding to the immunopathological destruction of myelin. Demyelination is in part the result of direct virus destruction of oligodendrocytes but also the consequence of immune and inflammatory responses. Other viral models of demyelination include mice with JHM and MHV-4 virus coranoviruses infection, dogs with canine distemper virus, and sheep and goats with Visna virus and caprine arthritis-encephalitis virus.

An animal model of virus-induced demyelination with no relapses is the Semliki Forest virus SFV infection of mice [ 93 ]. All viruses are capable of establishing persistent viral infection over a long period without inducing mortality of the host.

Multiple sclerosis - Symptoms and causes - Mayo Clinic

All of these examples make a case for the viral hypothesis of CNS demyelination. Many studies have demonstrated antibody titers to a broad range of pathogens in MS patients; however, many of these findings remain solitary and unconfirmed.

EBV is a B-lymphotropic human DNA herpes virus that infects most individuals asymptomatically but causes infectious mononucleosis IM in some [ 9596 ].

Another study demonstrated the increased risk of MS in individuals with a clinical history of IM [ 9899 ].

autoimmune process and its relationship to ms

As previously shown in other studies, MS highly correlated with IM []. As a control, the authors also examined correlations of MS with cytomegalovirus prevalence and varicella prevalence, respectively, both of which were not correlated with MS.

autoimmune process and its relationship to ms

It has been suggested that low vitamin D levels result in immunosuppression that lead to an increase in EBV infection. It is also known that a low amount of UVB decreases vitamin D levels. The geographical variation in the MS prevalence, with a higher prevalence of the disease in northern latitudes and a lower prevalence at the equator, is well established [ — ].

This variation in MS prevalence correlates positively with changes in the serum concentrations of hydroxyvitamin D [ — ]. Several, but not all, studies show an inverse correlation between serum hydroxyvitamin D concentrations and the incidence of MS, the severity, and progression of disease [ — ].

Vitamin D, and its biologically active metabolite 1,dihydroxyvitamin D3 1,25 OH 2D3not only plays an important role in the regulation of calcium and phosphorus homeostasis but also is an important modulator of immune function. It is a self-perpetuating process in that one subtype inhibits the generation of the other []. The primary generation of Thtype T-cell responses is potently inhibited by 1,25 OH 2D3 both in vitro and in vivo. The in vitro effects of 1,25 OH 2D on the immune system.

The effects of 1,25 OH 2D either directly or indirectly are depicted by arrows. While a green arrow represents positive influence, a red arrow represents the negative influence. The negative influence on inflammation indicates dampening of the inflammatory response. T helper type 1 lymphocyte; Th2: T helper type 2 lymphocyte; Tr: Antibodies, through molecular mimicry, may recognize autoantigens of the CNS and can also injure the oligodendrocyte by binding to the surface of the cell and, in association with complement, may induce direct injury to myelin or the oligodendrocytes.

This partially leads us to the autoimmune hypothesis. The oligodendrocyte may die as a consequence of direct and persistent virus infection. These mechanisms of injury may be independent or occur concurrently in each brain. All of these mechanisms lead to demyelination that the host may correct by transient remyelination. Ultimately, the demyelination process overtakes remyelination resulting in axonal damage, thus leading to permanent neurologic deficits.

At the present time, there is no clear evidence that these patterns of injury relate to various stages of the disease course and do not correlate with the clinical subtypes of relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, or primary progressive multiple sclerosis, although this is yet to be determined. Many of the observed findings have subsequently led investigators to false conclusions regarding MS pathogenesis.

Immune cells are present in the MS plaque, and the immune system is important in the pathogenesis of the disease because a number of immunomodulatory and immunosuppressive therapies do decrease relapses and the number of gadolinium-enhancing lesions in MS brain. However, the long-term consequences of immunosuppression on disease course are unknown because most published clinical trials end after two years of observation, an insufficient period of time to address the long-term consequences of these treatments.

Therefore, it is critical to identify the specificity of these bands. Ultimately, it may be proven that CSF oligoclonal IgG bands play a neuroprotective rather than a pathologic role [ — ]. Eriguchi is the recipient of a fellowship from Japan Brain foundation.

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No royalties have accrued to Dr. Rodriguez or Mayo Clinic to date, but both have rights to receive future royalties. View at Google Scholar E. Myelin can be compared to the insulation coating on electrical wires. When the protective myelin is damaged and nerve fiber is exposed, the messages that travel along that nerve may be slowed or blocked. The nerve may also become damaged itself.

It isn't clear why MS develops in some people and not others. A combination of genetics and environmental factors appears to be responsible. Risk factors These factors may increase your risk of developing multiple sclerosis: MS can occur at any age, but most commonly affects people between the ages of 15 and Women are about twice as likely as men are to develop MS.

If one of your parents or siblings has had MS, you are at higher risk of developing the disease. A variety of viruses have been linked to MS, including Epstein-Barr, the virus that causes infectious mononucleosis.

White people, particularly those of Northern European descent, are at highest risk of developing MS. People of Asian, African or Native American descent have the lowest risk. MS is far more common in countries with temperate climates, including Canada, the northern United States, New Zealand, southeastern Australia and Europe. You have a slightly higher risk of developing MS if you have thyroid disease, type 1 diabetes or inflammatory bowel disease.