How are DNA, chromosomes, genes, and alleles related? | Socratic
This chapter will explore some of the basic characteristics of genes, and the experimental .. This correlation of the behavior of alleles in matings and the movement of where you had to copy, e.g. a poem, from a book onto your paper - you. Our study reveals widespread additive, trans-acting pairwise effects on gene modules, are focused on epistatic relations and thus have limited utility for the case of effect of one locus is dependent on the particular alleles in the other locus. Alleles are different forms of same gene. Genes are linearly arranged on chromosomes. Chromosomes contain genetic material of cell i.e. DNA.
For each P-value cutoff the true positive, true negative, false positive and false negative counts are then calculated. Next, the area under the receiver operating characteristic ROC curve is computed on the basis of the resulting counts, referred to as the accuracy score. The accuracy score ranges between 0 for a random solution and 1 for an optimal solution.
Since true positive pairwise effects can rarely be detected randomly, an accuracy score of 0.
Frontiers | POEM: Identifying Joint Additive Effects on Regulatory Circuits | Genetics
We note that the accuracy score is obtained by testing a range of P-value cutoffs, which is the main parameter of interest and serves as input in all compared methods. In all cases, these cutoffs refer to the maximum P-value attained by the primary and secondary eQTLs.
To assess the difference in accuracy between two different methods we compared the corresponding ROC curves using a paired t-test comparing specificity for the same sensitivity levels.
Gene expression dataset of bone marrow-derived dendritic cell across 43 BXD strains was compiled from a Supplementary Table in a previous publication Gat-Viks et al. RNA levels were measured in genes at steady state and 6 h after in-vitro stimulation with one of three pathogenic components: A gene's response to a given stimulation in a given strain was calculated as the difference between the log-transformed expression levels at 6 h after stimulation and at steady state.
Using these parameters, POEM runs for about 2 min to analyze the entire mouse dataset, consisting of traits across 43 strains.
A trans-acting poeModule cis-acting poeModule is defined as a poeModule whose fraction of trans-trans-affected traits is above below 0. The TLR signaling model for poeModules MM18 was generated by adding all target genes whose promoters were bound to the transcription factors Nfkb1,2, Irf3,7, or Stat1,2 1.
And for redoing and redoing. I love the way you've embedded the Fibonacci in the 5 times 4 line structure. All the repetitions and half repetitions are just right. Hope you feel it stands as a poem in itst own right as well as words for music. Love that you keep the final sentiment from your final poem. Hope to speak later in the week.
I too feel god with small g would be better - what do you think? Michael wanted something much more mathematically patterned to fit in with what he wanted and you wanted, so I did him an extra one of his own, using some of the language and images from the sequence.
We are still tinkering with tiny details, but he is happy with this. I've taken the liberty of tweaking a few tiny things. I think you will see this as disturbing your poetic metre, in fact I'm sure you will!
Without it the music can just begin straight in - with it I have to set this word as some kind of upbeat - and I can only say this is something I really would like to avoid as it will at the very start stop up the flow. But if it is singular and personal, I feel it brings the subject closer to a listener and to the singers - they will be able then sing 'to' the allele and not just about it.
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- Alleles and genes
If it is, it supports still more the singularisation. But I hope you'll understand why - it will allow the music to flow fully out of your beautiful words, and at no time be blocked by them. I don't know if this is a problem or not Mystery of the tiniest difference.
How are DNA, chromosomes, genes, and alleles related?
Allele, shadow in the mirror of the self, invisible. Tiniest freckle on a silver sea when dawn scatters autumn cloud. Stranger who should be welcome in your home, stranger who might also be god. Allele — will be repeated…! Maybe you are right about God. Flight of the tiniest humming-birds, in sequence: Fireflies, invisible, occult as Kabbalah, tiniest wings folded over lightning glow, sleeping in the mysteries of day. Plankton, invisible in the pelagic zone till they become a mystery of the moon, tiniest shooting stars, unknown sparks in black water racing behind the skiff.
Mystery of the tiniest difference, barcode occult as Kabbalah: The Other, the unknown, embedded in the sequence and revealed in song. The Stranger who should be welcome in your home for Stranger might also be God. Mentioning the Gulf of Mexico for me pushes it in a completely different and too localised direction as though the main subject is migration of specific humming birds - and not alleles! Could you possibly be happy to turn it back exactly to where it was which felt just perfectly balanced 'migrating' as it was placed being both about the birds, and somehow about the genetic differences too and right for me?
I really hope so. I guess I'm concerned it becomes strangely conventionally religious -which i'm sure you don't mean at all - with the big G.
I've sent you another version keeping your tweaks and changes but going back to the substance of verse 1. Could we be there?!
Plankton, invisible in the pelagic zone, till they become a mystery of the moon, tiniest shooting stars, unknown sparks in black water, racing behind the skiff. A barcode occult as Kabbalah: The stranger who should be welcome in your home, for stranger might also be god. The mystery of migrating, crimson wings above an unknown sea. Invisible fireflies, sleeping, occult as Kabbalah, tiniest wings folded over lightning in know, bright mysteries of day.
Plankton, invisible in the pelagic zone till they become a mystery of the moon: Allele, invisible shadow in the mirror of the self, occult as Kabbalah. Tiniest freckle visible on sea, when dawn scatters autumn cloud.
The writing of Allele (Ruth Padel)
The Other, the unknown. Embedded in the tinest difference and revealed in song. A stranger who should be welcome in your home for stranger might also be god. I'm learning much about writing poetry But I've changed a bit: Is it too bare?
Perhaps it disturbs your rhythm - but it feels fine to me. I feel I should never had set this running at all now - I'm sorry.
Crimson wings above an unknown sea, in the mystery: Fireflies, invisible, occult as Kabbalah, tiniest wings folded over lightning glow, sleeping, in the bright mysteries of day. Plankton, invisible in the pelagic zone, till they become a mystery of moon: Allele, invisible, shadow in the mirror of the self, occult as Kabbalah: Tiniest freckle visible on unknown sea, when dawn scatters autumn cloud.
Embedded in the tiniest difference and revealed in song. And the sequence of base pairs is really the information content in DNA, and here I've just kind of drawn it as a, as a ladder.
We know that the real structure of DNA is a is kind of this twisted ladder, this double helix. Now if we talk about this whole yellow squiggly line, and it could be even a section of a longer yellow squiggly line, this could code for multiple for multiple things, especially multiple proteins.
So different regions of this could code for different proteins.
So for example, this section right over here could be part of this region that I'm highlighting in blue that codes for a specific protein, and so we would call this a Gene. We would call this a Gene. This might be a protein that is involved in, I don't know, I'll make something up. It's a protein that evolved, that's involved in the immune system. Maybe, maybe this stretch, let me do it in different color. Maybe it codes, it codes for a protein that's used-- Maybe it's a protein that helps regulate DNA replication.
Maybe over here is another we encode for another protein that maybe, maybe it in some ways affects, affects the pigmentation of your skin, or the pigmentation of your eyes, and so you these stretches of DNA that code for specific things.
And actually it doesn't have to just be even for a protein. That gets processed so you could actually lose some sections of it, but you go to messenger RNA and then that messenger RNA, every three of these base pairs is a Codon.
Let me, so let's say that's one codon. One, two, three, that's another codon. One, two, three, each of those-- Maybe I'll draw them next to each other. Each of of them codes for an amino acid that is kind of connected together to form, connected together to form a protein.
So that's one amino acid right over there.Gene, Locus, Allele, Phenotype, Genotype Genetics Terminology in Urdu - 12 Class Biology #279
This could be another amino acid right over there. We can keep going on and on and on and on.
You could have another Amino Acid right over here, and then they all bond to each other and they're brought actually to the mRNA from a, by a functional RNA group. And so there are functional things other than proteins that this could code for.